Miguel A. Munoz-Lorente
- Sep 26, 2018
- 3 min
Telomerase Gene Therapy treatment of age-related diseases and telomere syndromes does not favor canc
Telomeres are protective structures at the ends of chromosomes. They consist of tandem repeats of a DNA sequence, which in all vertebrates is TTAGGG, bound by a six-protein complex known as shelterin that exerts the protective function. Telomeres shorten every time a cell divides, and when they become critically short, this induces a persistent DNA damage response (DDR) at chromosome ends which can jeopardize cell viability. In the context of the organism, telomeres shorten a
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